CD27 is heterogeneously expressed in multiple myeloma: low CD27 expression in patients with high-risk disease

CD24, CD27, CD36 and CD302 gene expression for outcome prediction in patients with multiple myeloma

Multiple myeloma (MM) is a B cell neoplasia characterized by clonal plasma cell (PC) proliferation. Minimal residual disease monitoring by multi-parameter flow cytometry is a powerful tool for predicting treatment efficacy and MM outcome. In this study, we compared CD antigens expression between normal and malignant plasma cells to identify new potential markers to discriminate normal from mali...

Cd27 Cd70 Is Downregulated by Interaction With

Activated CD27+ and CD27- memory B cells accumulate in the joints of patients with juvenile idiopathic arthritis

The expression of the costimulatory molecules CD80 and CD86 was increased on synovial fluid CD19+ B cells as compared to peripheral blood. CD80/CD86 expression on these B cells could be shown to induce alloreactive T cell proliferation in vitro. Most of the synovial fluid B cells belonged to the CD27+IgDclass-switched memory B cell subset. However, almost half of the CD27 negative synovial B ce...

Expression and release of CD27 in human B-cell malignancies.

CD27, a transmembrane disulfide-linked 55-kD homodimer, belongs to the nerve growth factor-receptor family, a group of homologous molecules involved in lymphocyte differentiation and selection. It is expressed on mature thymocytes, peripheral blood T cells, and a subpopulation of B cells. We investigated the expression of CD27 on malignant B cells representative for a broad range of stages in p...

pVHL/HIF-regulated CD70 expression is associated with infiltration of CD27+ lymphocytes and increased serum levels of soluble CD27 in clear cell renal cell carcinoma.

PURPOSE CD70, a member of the TNF ligand superfamily, has been shown frequently overexpressed in clear cell renal cell carcinoma (ccRCC). The mechanisms of CD70's upregulation and its role in ccRCC are unknown. EXPERIMENTAL DESIGN CD70 expression was immunohistochemically analyzed in 667 RCCs and RCC metastases. Von Hippel-Lindau gene (VHL) mutations, expression patterns of VHL protein (pVHL)...